| 초록 |
The evaporation crystallization should be non-uniform easily without specific conditions. This phenomenon occurs because of random evaporation rate from each part of solution surface. If local evaporation rate was controlled by evaporation parameters like temperature gradient, flow rate of evaporation, we might be able to engineer crystal structures. In this study, we controlled evaporation crystallization of active pharmaceutical ingredient (API) and polymer in volatile solvent. The structure of crystal could be inhibited or enhanced depending on confined flow system. Demonstration of evaporation flow effect on unique crystal morphology and modification of polymer surface. The fabrication of uniform crystal structure is based on where the solution nucleates with the immediate evaporation of the solvent through growth of crystal. |
