| 초록 |
Propionibacterium acnes (P. acnes) is a major cause of acne. Acne treatment is mainly based on antibiotics, but the development of drug-resistant strains has reduced its therapeutic effect. Photodynamic therapy (PDT) produces reactive oxygen species (ROS) when light is irradiated, which is a promising strategy for treating bacteria. However, ROS without specificity can kill not only bacteria but even normal cells. Therefore, selective treatment of target bacteria is an essential strategy. In this study, enzyme-responsive liposome loaded with PS and antibiotics (ERLPA) for combination of photodynamic and anti-bacterial therapy for P. acnes which secrete extra-cellular esterase. ERLPA, composed of lipids containing ester bonds, releases antibiotics and photosensitizers when exposed to the enzyme of P .acnes. As a result, the simultaneous action of antibiotics and PS confirmed the excellent therapeutic effect aginst P. acnes was demonstrated by in vitro and in vivo experiments. |
