| 초록 |
An enzyme-sensitive singlet oxygen-producible and antibiotics-loaded liposome (ESSPAL) was developed for combination antibacterial treatment for acne. The ESSPAL was synthesized by coating hydrophilic polymer-photosensitizer (HP-PS) conjugates onto antibiotics-loaded liposomes composed of phosphatidylcholine (PC) and cholesterol. Enzyme activity was chosen as the environmental-stimulus for the controlled release of antibiotics and PS from ESSPAL because skin inflammation-inducing Propionibacterium acnes(P. acnes) secrete extracellular enzymes. The presence of enzymes of P. acnes disrupted ESSPALs by selective cleavage of their ester linkages, liberating antibiotics and PS. Along with the antibacterial effect of antibiotics, additional laser irradiation onto PS further achieved the inhibition of P. acnes growth. Therefore, antimicrobial therapy, using enzyme-responsive moiety, presents a feasible way to treat bacteria-induced skin disorders. |
