| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Lipase-responsive transfersomes for Photodynamic Therapy of Acne |
| 초록 |
Acne is a skin disease, known to be related to colonization of Propionibacterium acnes(P. acnes). Antibiotics(AB) is used to treat acne, but overdose of AB, causes antibiotic resistance(AR). The use of antibacterial photodynamic therapy(aPDT) may be a novel way to overcome the risk of AR. But, PDTs can be toxic by the reactive oxygen species(ROS), regardless of normal cells and bacteria. In this study, the transfersome(LSPT) was developed using lipase sensitive lipid, deconstructed in the presence of lipase. LSPT consists of PEGylated lipids that contain PS and surfactants(SF). The addition of SF increases skin permeability. The photoactivity of LSPT is quenched, but gradually recovered by lipase. Photoactivity test exhibits an excellent antibacterial effect, confirmed by P. acnes survival rate. In vivo test is demonstrated by recovery of inflammation in acne-induced skin. These results demonstrate that LSPT-mediated aPDT has the potential as an alternative to acne treatment. |
| 저자 |
임병남1, 나건1, 박형1, 이종환1, 김민경2, 양수근2
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| 소속 |
1가톨릭대, 2인하대 |
| 키워드 |
antibacterial photodynamic therapy; transfersome
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| E-Mail |
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