| 학회 | 한국공업화학회 |
| 학술대회 | 2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 | 21권 1호 |
| 발표분야 | 나노 |
| 제목 | Synthesis of Nano size bio-capsule with siRNA and Gold Nanorods for Breast Cancer Therapy |
| 초록 | Therapeutic nanomaterials have been widely developed for the effective treatment of aggressive cancers because of their outstanding versatility, easy manipulation, and low cytotoxicity. In this study, we describe a bio nano capsule of bovine serum albumin engaged with both Bcl-2–specific siRNA and a gold nanorods for targeted breast cancer therapy. The bio nano capsule contained 2 × 105 siRNAs and eight gold nanorods per biocapsule and was successively functionalized with polyethylene glycol (PEG) and anti-ErbB-2 for active targeting. The bio nano capsule with intrinsic biocompatibility and multi-functionality is a highly promising therapeutic carrier for in vivo targeted cancer therapy and may have potential uses in various areas of nano-medicine Acknowledgements: This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIP) (No. 2015R1A2A2A01007843). |
| 저자 | 이명준, 염지나, 이은솔, 오병근 |
| 소속 | 서강대 |
| 키워드 | Nano; Cancer; Therapy |
