| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Sustained andControlled Release Behavior for Application of the Dual Drug-Eluting Stent |
| 초록 |
It is well known that the thrombus formation and the proliferation of the smooth muscle cells induced by injury after angioplasty of metal stents have generated in-stent restenosis inside them. To solve these problems the development of self-degradable scaffolds carrying drugs blocking/inhibiting the proliferation of the cells is urgently required. So the biodegradable polymers containing alpha lipoic acid (ALA), well known as blocking neointimal hyperplasia, and ReoPro (Abciximab), a potent inhibitor that blocks the final pathway of platelet aggregation, were served as a drug carrier. The hierarchical structure composed of three types of biodegradable polymer layers such as top, barrier, and bottom layers was formed onto the stent surface by electrospray coating for constructing the sustained and controlled release behavior of the dual drug for coronary stents. |
| 저자 |
김동민1, 이봉수1, 박귀덕1, 강종희1, 손태일2, 한동근1
|
| 소속 |
1한국과학기술(연), 2중앙대 |
| 키워드 |
stent; restenosis; ALA; ReoPro; electrospray
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| E-Mail |
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