| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Controlled release of bioactive molecules from biodegradable polymer for dual drug-eluting stent |
| 초록 |
Biodegradable and biocompatible polymers were used as a drug carrier for both alpha lipoic acid (ALA) and ReoPro. Main function of ALA is to increase production of glutathione and ReoPro is a potent inhibitor that blocks the final pathway of platelet aggregation. Since drug-eluting stent (DES) has been used for the patients of coronary artery disease, a novel concept of stent can significantly improve the coronary occlusion and restenosis. In this study, a hierarchical structure composed of three layers was formed on the stent surface using electrospraying or ultrasonic nanocoating. The release behaviors of dual drugs are of particular interest. The thickness of each layer was about 3~5 μm and the whole thickness was less than 10 μm. The release behaviors of dual drugs were significantly affected by the presence of a barrier layer within the polymer coating matrix. Current design of polymer coating may be useful in delivering multiple drugs at a time from DES. |
| 저자 |
김동민, 강종희, 최지연, 김준태, 박귀덕, 한동근
|
| 소속 |
한국과학기술(연) |
| 키워드 |
stent; biodegradable polymer; ALA; ReoPro; electrospray; ultrasonic nanocoating
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| E-Mail |
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