| 초록 |
Herein, we present ER-targeting, intracellular delivery technology that uses cell-attractive amphiphilic block copolymer-coassembled lipid nanovehicles. For this, we patch Penetratin, a type of cell penetrating peptide (CPP), for ER-targeting moiety as well as cellular uptake enhancer. We figure out that the Penetratin-conjugated nanovesicles fabricated in this study are readily uptaken by cells and show specific ER-targeting ability, which is quite comparable to the cases using other CPPs. Moreover, we observe that remarkable lysosomal escape occurs due to effective pH buffering with aids of amphiphilic block copolymer in the nanovehicles. These results highlight that our nanovehicles could pave the way for the development of elaborate delivery system for ER-targeting drug in intracellular level. |
