| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Apoptosis-inducing polypeptide via mitochondrial destabilization and malfunction |
| 초록 |
Cationic α-helical polypeptides have exhibited a high cell-penetrating ability and have generally been used as cell-penetrating peptides to deliver drugs or genes into cells. Mitochondria play a important role in inducing apoptosis in cells. In this context, we have developed a mitochondrial destabilizing polypeptide (MDP) using the cell-penetrating capability of cationic α-helical polypeptides. In order to confer mitochondrial-destabilizing ability to induce apoptosis of MDP, the lipophilic cation moiety was attached as a pendant to the side chain of the polypeptide. MDP showed high α-helical properties required for cell permeability and mitochondrial-destabilizing ability. MDP also showed an unprecedented high cytotoxicity and apoptotic signal in various cancer cell lines. MDP is likely to be applied in a variety of studies on cancer therapy in relation to unprecedented high mitochondrial-destabilizing capacity. |
| 저자 |
하종훈, 이대용, 김유천
|
| 소속 |
한국과학기술원 |
| 키워드 |
mitochondrial membrane destabilization; pro-apoptotic activity; anti-cancer polypeptide
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| E-Mail |
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