| 초록 |
The conjugation of multiple nanomaterials with different dimensions – 3D spherical NPs and 1D high aspect ratio nanotubes – may increase the target-specific antibacterial capacity while retaining the minimal toxic properties to the mammalian cells. In this study, the synthesized Cu-MWCNTs complexes were characterized by TEM, XRD and EDS. Cu-MWCNTs indicated effective antibacterial activity against Methylobacterium spp., Sphingomonas spp. and E. coli. evaluated by a paper disk diffusion and a MIC assay. The biocompatibility of Cu-MWCNTs were tested on human fibroblast cells with the minimum concentration required to have antibacterial properties. In addition, we confirmed to remove the biofilm in biochip and the mechanism. Reported Cu-MWCNTs carrying minimum Cu NPs may be desirable as a next generation antibacterial agent effective to various microbes while be biocompatible to mammalian cells. |
