| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | Proteomic and metabolomic analysis for investigation of antibiotic response in isogenic isolates of MRSA and MSSA |
| 초록 | Nowadays, the rapid spreadingof methicillin-resistant Staphylococcus aureus (MRSA) complicates thetreatment of infection. Thus, there were efforts to reveal the mechanism of thebacterial responses or resistance to antibiotics. However, previous research hasinvestigated responses to antibiotics without considering the geneticdifferences between methicillin-susceptible S. aureus (MSSA) and MRSA. Toaddress this problem, we explored the response to oxacillin using multiomicsapproach into the clinical isolates (i.e., WKZ-1 (MSSA) and WKZ-2 (MRSA)) thatare isogenic except for the genetic element (SCCmec type IV). The multiomicsdata shows that proteins involved in cell wall synthesis, two-componentsystems, oxidative stress, and stringent response were significantly changedafter the oxacillin treatment. In conclusion, we can reveal the response tooxacillin caused only by the antibiotic resistance-related genetic element using isogenic strains and multiomics approach. |
| 저자 | 조성현, 김민규, 권지은, 박지현, 김예림, 백지현, 권서영, 김윤곤 |
| 소속 | 숭실대 |
| 키워드 | MRSA; MSSA; Isogenic isolates; Multiomics; Antibiotics |
