| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
대학원생 구두발표 (영어발표, 발표15분) |
| 제목 |
Sequestering ATP inside Mitochondria by Nucleopeptide induces Cancer Cell Apoptosis |
| 초록 |
Mitochondria are essential organelles involving in cellular processes, especially adenosine triphosphate (ATP) production. ATP is a major energy source and can be a good eliminating target for anticancer therapy. We describe selective cancer treatment by sequestration of ATP and self-assemblies with ATP inside mitochondria using mitochondria-targeting nucleopeptide (MNP). We designed thymine containing MNP which can interact with ATP through electrostatic interaction and hydrogen bond between MNP and ATP. MNP exhibits selective higher binding affinity with ATP resulting in large complex and assemblies with ATP. MNP preferentially forms large assemblies with ATP even though MNP/ADP (adenosine diphosphate) complex is preformed after addition of ATP. Thus, sequestration of ATP and large assemblies of MNP/ATP inside mitochondria cause physical stress by large structures resulting in apoptosis. |
| 저자 |
최후연1, 유자형2
|
| 소속 |
1UNIST(Ulsan National Institute of Science and Technology), 2울산과학기술원 |
| 키워드 |
nucleopeptide• adenosine triphosphate • sequestration of ATP • self-assembly • anticancer therapy |
| E-Mail |
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