| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Drug-eluting stent covered with medium chain fatty acid for enhancing penetration of anticancer drugs |
| 초록 | Non-vascular drug-eluting stent (DES) has been considered a remarkable medical device for the treatment of bile duct, gastrointestinal stenosis. However, non-vascular DESs could not be commercialized due to low permeability and diffusion of eluted drug in certain tissues. We developed DES containing medium chain fatty acids (MCFA) as an enhancer of permeability for anticancer drug. MCFA has been used an enhancer in order to promote the absorption of various drugs such as heparin, insulin, and ampicillin. In DES incorporated with MCFA and anticancer drug, its exposed surface morphology and drug release profile were demonstrated in vitro. Also, drug penetration efficacy was higher than conventional DESs. Consequently, this platform has noticeable potential for local effective stent in anticancer therapy. |
| 저자 | 박진환1, 정두용1, 이돈행2, 이동기3, 나건1 |
| 소속 | 1가톨릭대, 2인하대, 3연세대 |
| 키워드 | drug-eluting stent; fatty acid; anticancer drug; enhancer |
