| 초록 |
Eutectic gallium-indium (EGaIn) has a low melting temperature with high compatibility. Under near infrared (NIR) irradiation, EGaIn leads to the elevation of temperature as well as the formation of reactive oxygen species (ROS). Herein, a interpenetrating network (IPN) hydrogel with 6-mercaptopurine (6-MP) attached thiolated gelatin and poly(ethylene glycol) diacrylate works as an injectable reservoir for EGaIn mediated multiple anti-cancer treatments: (1) photothermal effect by increasing temperature, (2) photodynamic effect by ROS, and (3) additional delivery of anti-cancer chemo-drug 6-MP. Temperature was increased over 50 ℃ by NIR irradiation. Moreover, EGaIn embedded hydrogel exhibited controllable and repeatable thermal stability for 5 on-off cycle. Furthermore, high temperature and ROS generation response to NIR irradiation were occurred cancer cell death. Therefore, our injectable EGaIn and 6-MP embedded IPN hydrogel could be applied to a multi-functional anticancer therapy. |
