| 학회 | 한국화학공학회 |
| 학술대회 | 2015년 가을 (10/21 ~ 10/23, 일산 KINTEX) |
| 권호 | 21권 2호, p.1665 |
| 발표분야 | 분리기술 |
| 제목 | Recrystallization of metformin particles using supercritical crystallization process |
| 초록 | In this study, the metformin particles were recrystallized by using the aerosol solvent extraction system(ASES) process. Supercritical carbon dioxide, which is known to be a green solvent, was adopted as an anti-solvent. Metformin, marketed under the tradename Glucophage among others, is an antidiabetic medication which is taken by mouth. It is the first-line drug of choice for the treatment of type 2 diabetes, in particular, in overweight and obese people and those with normal kidney function. The effects of process parameters such as temperature, pressure, solution concentration, and solution injection rate on particle size and its distribution were investigated. As a result, particle size decreased when the system temperature decreased and the system pressure increased. higher concentration of metformin in the solution and increasing the solution injection rate also increased particle size. |
| 저자 | 임종성, 조항규 |
| 소속 | 서강대 |
| 키워드 | 초임계유체; 메트포민; 미세입자 |
| VOD | VOD 보기 |
| 원문파일 | 초록 보기 |
