| 학회 |
한국재료학회 |
| 학술대회 |
2020년 가을 (11/18 ~ 11/20, 휘닉스 제주 섭지코지) |
| 권호 |
26권 1호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
SMALL-DIAMETER DECELLULARIZED BYPASS CONDUITS REINFORCED WITH ELECTROSPUN POLYMER FIBERS TO ENHANCE MATERIAL CHARACTERISTICS FOR LONG TERM BIOCOMPATIBILITY |
| 초록 |
Through the novel use of decellularized materials for vascular reconstruction, many considerations on long-term biocompatibility and patency require further investigations. The study aims to integrate decellularization and electrospinning principles in obtaining a biocompatible scaffold with high efficiency and provide structural effectivity. Decellularization was used to eliminate a significant portion of genetic material to the host and render the structural integrity of the extracellular matrix (ECM) intact throughout the process. However, the considerations on the use of such principles involve the varying degree of decellularization and the integrity of material after such a process. Furthermore, the use of decellularized arteries provided a much weaker framework resulting in lower mechanical properties and a higher risk of atherosclerosis formation as reported in different literatures. Electrospinning has provided an avenue in creating vascular constructs with varying vessel diameters through the use of solution-based polymers. The structure resembles the high surface area of ECM structures provided with tunable pore sizes for nutrient distribution as well as cell migration. Limitations of electrospinning involve the absence of adhesion sites that allow immediate cell attachment to induce proliferation. The corresponding study aimed to provide an artificial bypass conduit comprised of decellularized arterial structures reinforced with polymeric fibers to increase the mechanical properties and the biocompatibility of the structure. The material was characterized by tensile, burst strength, and contact angle testing. Biocompatibility was assessed using the proliferative capability of scaffold and its corresponding hemocompatibility assessment. |
| 저자 |
John Patrick Cuenca1, Lee Byong Taek2
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| 소속 |
1Department of Regenerative Medicine, 2College of Medicine |
| 키워드 |
Blood vessel; Decellularization; Electrospinning; Biocompatibility
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| E-Mail |
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