| 초록 |
Many techniques have been developed to improve the effect of the drug required to human health or to control the release rate. Since it directly controls the bioavailability, controlling crystal size and shape of drugs is important in biomaterial and pharmaceutical industry. By using the drowning-out crystallization, a crystallization methods, we induced polymer-directed nucleation and growth for meso crystal phases prior to the regular crystallization steps. In this study, the size and shape of the crystals was controled by adjusting the ratio of the amounts of drug and polymers. Additionally, the flow rate of non-solvent and temperature was controlled too. For the experiment, the drug used was atorvastatin known as a cholesterol-lowering medication and the polymer was polyacrylic acid, etc. From the optical microscopy, the crystals of atorvastatin showed a needle shape of particles, but atorvastatin with polyacrylic acid showed a distinct proof of growth inhibition of needle crystals. |
