| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
생체활성 조직유도 고분자(의료용고분자부문위원회) |
| 제목 |
Bioactivation of scaffold surface using peptide for enhanced tissue regeneration |
| 초록 |
Surface modification of scaffold using bioactive molecules tissue regeneration has been a high demand in the development of clinical regenerative medicine. Herein, identification/ application of bioactive peptide domain onto the scaffold surface will be discussed. Peptides were isolated from various growth factors/extracellular matrix protein and examined their activities through cell growth test, differentiation activity. The peptides were able to present apatite formation. Scaffold surface alone was not able to induce noticeable mineral creation however, mineralization was evident with the peptides, implying that the peptide played a pivotal role in biomineralization. In vivo result further demonstrated that the peptide with material was able to induce bone formation in the bone defect. Taken together, the peptide herein and its assembly with scaffold surface can be applied as an inducer of biomineralization as well as a bioactive scaffold for bone regeneration. . |
| 저자 |
Jue Yeon Lee1, Young Suk Choi2, Jin Sook Seo2, Yoon Jung Choi2, Jun Beom Park2, Sang Chul Lee1, Seung Jin Lee3, Chong Pyoung Chung2, Yoon Jeong Park2
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| 소속 |
1Seoul National Univ. / NIBEC, 2Seoul National Univ., 3Ewha Womans Univ. |
| 키워드 |
Bioactive Surface; Scaffold; Peptide; Tissue Regeneration
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| E-Mail |
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