| 초록 |
A biocompatible nanogel [n-Dxt-p(lactide)] was developed using dextrin and lactide through in-situ crosslinking with MBA crosslinker by free radical polymerization technique for delivery of anticancer drug. The developed nanogel has been characterized by FTIR, 1H NMR, TGA, TEM and DLS analyses. TEM analysis confirmed that the nanogel size was within 10 nm in diameter. Degradation study of the nanogel has been carried out using hen egg lysozyme. In vitro cytocompatibility studies against human mesenchymal stem cell (hMSCs) suggested that the nanogel is non-toxic. The nanogel can effectively load doxorubicin hydrochloride (Dox) within the matrix. The native nanogel is non-toxic for MG 63 cancer cells, whereas, Dox-loaded nanogel demonstrated high toxicity towards cancer cells. The n-Dxt-p(lactide) nanogel can easily penetrate into the cell cytoplasm and devastate cancer cells, owing to the very small size. |
