| 초록 |
The needs for microspheres made of biodegradable polymers have gradually increased with the developments of bioactive delivery systems, tissue engineering, and regenerative medicine. The microspheres have been prepared by various methods including freezing and incorporating gas pocket. In these days, polycaprolactone is widely used as a bone substitute material, however, it poses poor osteoconductive capacity for bone regeneration. Hyaluronic acid is a naturally occurring non-immunogenic glycosaminoglycan and plays a significant role as a facilitator of osteogenesis for stem cells. In this study, PCL/HA hybrid microspheres were simply prepared by a spray/precipitation method using a double nozzle spray. From the in vivo animal study using rats, PCL/HA microspheres showed more enhanced bone regeneration than the blank and PCL microspheres. From the results, we could suggest that the PCL/HA microspheres can be a good candidate as a bone filler substrate for the bone regeneration. |
