| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
신진연구자 특별 심포지움 |
| 제목 |
Corneal wound healing effects of secretomes derived from hMSCs cultured on electrospun fibers |
| 초록 |
The therapeutic effects of secretomes produced by bone marrow-derived human mesenchymal stem cells (MSCs) were evaluated as a function of their growth in 2D culture conditions and on 3D electrospun fiber scaffolds. The secretome produced by the MSCs cultured on fiber matrices versus 2D culture dishes were analyzed, and the secretome of MSCs showed substantial compositional differences. In vitro proliferation and scratch-based wound healing assays were performed to compare the effects of the secretome on corneal fibroblast cells (CFCs). Electrospun fibers seeded with MSCs were then applied to a rabbit corneal organ culture system, and MSCs seeded on fibers promoted faster epithelialization. Future work is merited to further understand the nature and basis of these differences and their effects in animal models. |
| 저자 |
이현종 |
| 소속 |
가천대 |
| 키워드 |
Secretome; Electrospinning; Corneal wound healing
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| E-Mail |
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