| 초록 |
To date, small-molecule CT contrast agents have been used frequently for CT imaging to improve contrast enhancement of the vascular system. However, these small-sized agents are excreted rapidly through kidneys, often resulting in significant renal toxicity and requiring high injection dose. To overcome these problems, recently, our group and other researchers reported on nano-sized CT contrast agents with increased blood half-lives. As part of our continued efforts, we developed single-MW macromolecular CT contrast agents, which not only have nano-sized properties, but also have ultimate reproducibility and homogeneity like small molecules, that is rarely achieved in nanomedicine. Specifically, high iodine-content modular building blocks were used in combination with diverse types of core molecules customized for various purposes, such as biodegradability. We envision that our approach may provide first step toward realizing commercialization of nano-sized CT contrast agents. |
