| 초록 |
Doxorubicin, a Cytotoxic Anthracycline Antibiotic derivative, has anticancer effects in vitro and in vivo. Epithelial ovarian cancer is not only the most common type of ovarian cancer but also the leading cause of death from gynecological malignancy. Many studies have uniformly indicated that there is a close relationship between the frequency of ovulation and the development of epithelial ovarian cancer. Apoptosis can occur at therapeutic concentrations of anthracyclines. Apoptosis is the process of programmed cell death or cell suicide. Apoptosis typically affects single cells that are aged, dysfunctional, or damaged by external stimuli. Doxorubicin showed inhibitory effects on cell growth and induced apoptosis. The data showed that growth inhibition of drugs were time and dose dependent. Cell viability was decreased for 72 h, but the activity of LDH did not increase. These findings indicated that doxorubicin has growth inhibitory effects and did not show direct cytotoxic effects. |
