| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
나노 |
| 제목 |
Label-free multi-detection of cancer biomarker by using a nanoplasmonic biosensor |
| 초록 |
Highly sensitive, selective and multiplex sensors have become an important challenge for disease diagnosis. Here, we describe a multiplex biosensor for the detection of cancer biomarkers based on distinct plasmon response of single gold nanoparticles (AuNPs) and antibody-antigen binding activity. To demonstrate the ability to detect and quantify cancer biomarkers: a panel of biomarkers of α-fetoprotein (AFP), Carcinoembryonic antigen (CEA) and prostate specific antigen (PSA) was used as a model analytes. A multiplex biosensor was developed by site-selectively immobilizing plasmonic nanoparticles functionalized with an each monoclonal antibodies that recognize the target protein on patterned glass slide. The proposed biosensor exhibited outstanding selectivity and sensitivity. |
| 저자 |
이정섭, 이종욱, 심상준
|
| 소속 |
고려대 |
| 키워드 |
nanoplasmonics; label-free detection; cancer
|
| E-Mail |
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