| 초록 |
Plasmonic nanomaterials have noble optical properties for biosensors. Nanoplasmonic biosensors have become simple, sensitive, smart, and consistent with advanced healthcare programs requirements. An individual nanoparticle analysis can yield unique target information, based on which the biosensor is revolutionary for end-point detection, and can be functionally extended to biological phenomena monitoring. Here, we present a single nanoplasmonic biosensor based on localized surface plasmon resonance for label-free and real-time detection of cancer biomarkers in clinical samples. The sensor detects mutant DNA, and can detect telomerase from as few as 10 HeLa cells. This approach can be translated to detect other pathological targets with high sensitivity and specificity, and monitor key interactions between biomolecules in real time. This system has great potential to be further developed for on-chip and simultaneous analysis of multiple targets and interactions. |
