| 초록 |
In this study, a simple creation of a cell-adhesive poly(vinyl alcohol) (PVA)-microstructures on a bio-inert substrate using ion beam contact lithography is described to control the adhesion of live cells. PVA thin films spin-coated on a bio-inert polystyrene (PS) substrate were patterned by a proton beam irradiation through a pattern mask followed by developing with water. The analytical results revealed that 100 μm negative-tone robust PVA microstructures were successfully formed on the PS. Moreover, based on the results of the protein adsorption and cell culture, cells grew preferentially onto the PVA regions of the micropatterned substrate, resulting in the creation of well-ordered arrangement of cells. |
