| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I (영어발표) |
| 제목 |
Modular Dendron Micelles for Controlled Cellular Interactions |
| 초록 |
Nanoparticles (NPs) with positively charged surfaces (e.g. –NH2 termini) are known to non-specifically interact with cells and cause toxicity via membrane destabilization, which can be diminished by charge neutralization or carboxylation. However, the relationship of end-group charge effect and PEG chains surrounding the NPs have not been systematically understood despite their critical roles played in determining cellular interactions of NPs. This presentation will focus on our recently obtained results that demonstrated the modularity of dendron micelles (DMs) in controlling their cell interactions based on thier surface charge and PEG chain length. These results support the potential of DMs as a novel delivery platform that displays a high level of controllability over thier biological interactions. |
| 저자 |
Seungpyo Hong |
| 소속 |
Univ. of Illinois |
| 키워드 |
Dendron; cell interaction; surface charge; PEG; micelle
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| E-Mail |
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