| 초록 |
The development of broadly applicable catalytic methods for the sustainable production of chiral amines and unnatural amino acids has been identified as a key research priority by the pharmaceutical industry. Among different biocatalysts, ω-transaminases (ω-TAs) have recently received a great deal of attention as promising catalysts due to their ability to produce a wide range of optically pure amines and unnatural amino acids. ω-TA reaction has many desirable features when compared to other enzymes such as hydrolases and dehydrogenases, including broad substrate specificity, high enantioselectivity, high turnover number, and no requirement for regeneration of external cofactors. Here, our recent efforts to produce optically pure unnatural amino acid by using ω-TAs will be presented. |
