| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Anticancer effect of Pegylated-chlorambucil Prodrug nanoparticles for Cancer Therapy |
| 초록 |
Chlorambucil (CLB), which was used as a leukemia curing agent, proved its anti-cancer effect in a recent study. CLB has the disadvantage such as high toxicity, MDR effect, and poor solubility in water. To overcome a these obstacle, we synthesized pegylated-CLB prodrug nanoparticles with coupling agent. Its chemical structure was confirmed by 1H-NMR and UV-vis spectrophotometer. To demonstrate a solubilization of CLB against water, solubility test was conducted according to various concentration of prodrug, which was measured by using UV-vis spectrophotometer. Its particle size and morphology were analyzed by DLS and TEM. Beside, anticancer effect was confirmed by using MTT assay. Cellular uptake of that was analyzed by using fluorescence microscopy and flow cytometry. (NRF-2016H1D5A1910499). |
| 저자 |
정경원1, 정은희1, 홍웅길1, 안준혁1, 박준규2, 나재운1
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| 소속 |
1순천대, 2(주)시지바이오 |
| 키워드 |
Chlorambucil; Pegylated-chlorambucil; Prodrug; Anticancer effect
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| E-Mail |
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