| 초록 |
Pharmaceutical co-crystallization has been a well-known method for enhancing drug performance. A co-crystal is defined as a homogenous crystalline material containing multi components. Unfortunately, many co-formers reported so far are not preferable, since they are not generally regarded as safe excipients. This is a reason why the commercialization of reported co-crystals has never been popular. In this experiment, we tried co-crystallization between polyphenols (co-formers) and carbamazepine (drug). Polyphenols were usually extracted from fruits or vegetables, known as anti-oxidants. For carbamazepine, naringenin, one of polyphenols, was selected and their co-crystal was successfully formed. The 1:1 stoichiometric ratio of naringenin and carbamazepine was proper for the co-crystallization, and the co-crystal structure was identified by the single-crystal X-ray diffraction method. The co-crystal showed dehydration resistance and a lowered solubility in water. The co-crystallization of carbamazepine and naringenin could be utilized to recover the drug from drug-polluted waste water to solve the wastewater problem of carbamazepine. |
