| 초록 |
Amphiphilic block copolymer, especially containing stimuli-sensitive segments, have been widely investigated in pharmaceutical and biomedical fields due to their unique characteristics of self-association and response on external stimulus. Amoung various stimuli-sensitive materials, poly(N-isopropylacrylamide) (PNIPAAm) have been frequently employed for temperature sensitive moiety because of the extended coil to globule transition of the aqueous solution (lower critical solution temperature, LCST) near physiological temperature. Until now, several methodologies such as optical transmittance changes, light scattering properties, and heat exchange during the transition have been utilized for the determination of the transition behaviors. In this research, 1H NMR and micro-DSC were employed for microscopic investigation of the transition behavior of PNIPAAm-PCL and PEG-PCL based thermosensitive polymeric micelles. |
