| 초록 |
chitosan (CS) and CS-graphene oxide biocomposite nanofibers have been successfully prepared using aqueous solution by electrospinning. CS colloidal gel in 1% acetic acid can be changed to homogeneous solution by using electron beam irradiation (EBI). Viscosity average molecular weight of CS was reduced from 78.7×104 to 1.4×104 by electron beam irradiation (EBI) in order to improve its solubility. The uniform distributions of GO sheets in the nanofibers were investigated by field emission scanning electron microscopy (FESEM) and Raman spectroscopy. FESEM images illustrated that the spread single GO sheet embedding into nanofibers was formed via self-assembly of GO sheet and PVA/CS chains. And the average diameters of the biocomposite nanofibers decreased (200, 173, 160 and 123 nm) with increasing the contents of GO (0.05, 0.2, 0.4 and 0.6 wt%). The highest tensile strength of composite nanofibers was 2.78 MPa, which was 25% higher than that of neat PVA/CS nanofibers. Antibacterial test demonstrated that the addition of GO to PVA/CS nanofiber had great ability to increase inhibition zone till 8.6 mm. Overall, as-prepared CS-based nanofibers from eco-friendly system can be a promising candidate material in tissue engineering, wound healing and drug delivery system. |
