| 초록 |
Complex coacervation is a liquid-liquid phase separation, or liquid droplets formation, phenomenon that occurs when two oppositely charged macromolecules are interacting for net charge neutralization. From food additives to biotechnology, coacervates are applied in various research areas. From our previous studies, fucoidan, a marine-derived glycosaminoglycan, and poly-l-lysine (PLL) coacervates have shown promising protein delivery; sustained release profile, superior encapsulation ability, biocompatibility, and protection against harsh in-vivo environment, for cancer immunotherapy and tissue engineering applications. In this study, to surpass current wound healing patches, fucoidan was functionalized with dopamine (DOPA) to synthesize adhesive coacervate coating. DOPA conjugated fucoidan-PLL coacervate was successfully coated onto collagen sponge homogeneously. The coacervate coated collagen sponge showed promising adhesive and drug releasing properties for wound healing application. |
