| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ |
| 제목 |
Microbubble-Self-Aggregate Complex Used to Ultrasound-Mediated Enhanced Drug Delivery and Targeted Imaging |
| 초록 |
Microbubbles can be applied to a bifunctional material; ultrasound contrast agent and drug delivery carrier. Microbubble delivers the drug by conjugation of drug delivery carriers seems like liposome or nanoparticles. Under the intensive ultrasound condition, the microbubble proceeds to collapse and release conjugated nanoparticles. When the microbubble is collapsed, strong mechanical stress can occur at the site of the blood vessel and increased permeability. It is called microjet. By using this technique, we can control drug release at the target area by the selective exposition of ultrasound. In this study, a self-assembled nanostructure, a loaded hydrophobic drug, was chemically conjugated to microbubble. The size distribution of microbubble and self-assembled nanostructure were analyzed by dynamic laser scattering(DLS). And the conjugation ratio of microbubble and micelle was examined by UV-Vis spectroscopy. |
| 저자 |
박지호1, 안철희1, 정인재1, 문형원2, 이학종2
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| 소속 |
1서울대, 2분당 서울대 |
| 키워드 |
Microbubble; Drug delivery; Targeted imaging
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| E-Mail |
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