| 초록 |
The preparation of microcapsules usually needs two steps of shearing. With the development of microfluidic, the technology of top-down preparation of microcapsules has been applied to practical production. One-step controlled preparation of biocompatible oil-core microcapsules is of great significance for the industrial fabrication of microcapsules and their applications. In this abstract, biocompatible oil-core microcapsules with uniform and controllable size are successfully prepared via a one-step method using microfluidic devices. This method uses concentrically-aligned glass capillaries to prepare microfluidic devices. The inner oil phase is sheared into oil droplets by the outer hydrogel phase, which is then pulled off the orifice of the microfluidic device by gravity, forming oil-core microcapsules. The shells of the microcapsules are then cross-linked to form a stable hierarchical structure. The influences of microfluidic device design, inner phase and outer phase flow rates on the number of oil cores, microcapsules diameter and shell thickness are systematically investigated. As an ideal carrier for active substances, biocompatible oil-core microcapsules can achieve rapid release triggered by pH changes and slow release of wall thickness adjustment, laying the foundation for their practical applications. |
