| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
Direct CO2 conversion to α-farnesene, a precursor of high-performance polymer and biodiesel, using engineered Synechococcus elongatus PCC 7942 |
| 초록 |
Solar-to-chemical and solar-to-fuel production from CO2 have been developed using engineered microorganisms that assimilate CO2 and convert target chemicals and fuels. Herein, Synechococcus elongatus PCC 7942, a model cyanobacterium, was engineered to produce α-farnesene from CO2. Due to the lack of an endogenous activity of farnesene synthase (FS) in the wild-type cyanobacterium, we metabolically engineered S. elongatus PCC 7942 to express heterologous FS from either Norway source or apple fruit. To enhance α-farnesene production, an optimized methylerythritol phosphate (MEP) pathway was introduced in the farnesene-producing strain to supply farnesyl diphosphate. We demonstrated direct conversion of CO2 to α-farnesene using metabolically engineered cyanobacteria at the highest rate reported thus far (4.6 ± 0.4 mg/L in 7 days). This work was supported by Korea CCS R&D Center (KCRC) and Basic Science Program funded by NRF. |
| 저자 |
이현정1, 심상준2, 우한민1
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| 소속 |
1성균관대, 2고려대 |
| 키워드 |
farnesene; cyanobacteria; photosynthesis
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| E-Mail |
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