| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.495 |
| 발표분야 | 유ㆍ무기 나노섬유 소재 |
| 제목 | Surface modification of electrospun poly(ε-caprolactone) nonwovens using poly(vinyl alcohol) |
| 초록 | Poly(ε-caprolactone) (PCL) has been intensively studied among the aliphatic polyesters because it is hydrolysable in natural environments as well as in the human body. Electrospun PCL nonwovens have three-dimensional structure, high porosity with an interconnected pore structure, and a high surface-to-volume ratio1. However, electrospun PCL nonwovens have a hydrophobic characterization and cause a low adhesive to the scaffold2. Therefore, it is necessary to make some materials which are useful in biomedical applications by suitably modifying the surface characteristics of PCL nonwovens. Surface modifications or treatments are good methods for alternating the surface hydrophilicity3. To increase the surface hydrophilicity of electrospun PCL nonwovens, we developed an double-jet electrospinning coating method of poly(vinyl alcohol) (PVA) and solution coating method with dilute PVA solution. Since PVA is hydrophilic, the introduction of PVA within it increased the surface wettability of nonwovens and enhanced cell adhesion and proliferation. This convenient and effective method can be used to prepare bioactive scaffolds with extra cellular matrix (ECM)-mimic structure for tissue engineering. Fig. 1 shows electrospun PCL nonwovens and electrospun PCL nonwovens coated with PVA via electrospinning. In this work, we investigated the influence of the PVA coating on the surface of electrospun PCL nonwovens and cell adhesion and proliferation (a) (b) Fig. SEM images of (a) electrospun PCL nonwovens and (b) electrospun PCL nonwovens coated with PVA via electrospinning. Acknowledgement The authors thank the Korean Ministry of Science and Technology for financial support through the Center for Healthcare Technology Development References 1. K. H. Lee, H. Y. Kim, M. S. Khil, Y. M. Ra and D. R. Lee, Polymer 2003, 44(4), 1287-1294. 2. Shea LD, Wang D, Franceschi RT, Mooney DJ. Engineered bone development from a pre-osteoblast cell line on three-dimensional scaffolds. Tissue Eng 2000, 6, 605.17. 3. H. Tsuji, T. Ishida, Macromol, Biosci. 2003, 3, 51-58. |
| 저자 | 김치헌1, 이현욱1, 김학용1, 장광엽1, 길명섭2 |
| 소속 | 1전북대, 2헬스케어기술개발사업단 |
| 키워드 | Electrospinning; Poly(vinyl alcohol); Hydrophilicity |
