| 초록 |
Since polyglycolic acid (PGA) was used as first absorbable surgical suture in 1970s, a variety of biodegradable aliphatic polyesters have been widely used in biomedical fields as implantable or injectable materials such as surgical suture, orthopedic fixation implant, DDS carrier and tissue engineering scaffolds. At present, US FDA approved-biodegradable polyesters are polyglycolic acid, polylactic acid (PLA), poly-p-dioxanone (PPDO), poly-e-caprolcatone (PCL), polytrimethylene carbonate (PTMC) and recently polyglycerol sebacate (PGS) and polyhydroxy butyrate (PHB). Those biodegradable homopolymers and copolymers are processed to make surgical devices for soft and hard tissue implantable devices depending on those characteristics such as tensile strength, modulus, in vivo degradation rate. In this lecture, typical polymeric materials and products for synthetic bioabsorbable surgical suture and orthopaedic implants will be introduced. |
