| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Polysaccharide Based pH Responsive Terpolymeric Hydrogels for Biomedical Applications |
| 초록 |
Alginate (Alg), a polysaccharide was used to obtain the terpolymeric hydrogel by grafting 2-hydroxyethyl acrylate (HEA) to the hydroxyl groups of Alg. Further by adding appropriate quantity of poly(ethylene glycol) diacrylate (PEGDA), the hydrogels were cross linked and designated as AHP (Alg-g-pHEA-x-PEGDA hydrogels). The structure of the AHP hydrogels were characterized by FTIR, 1H-HR-MAS NMR, and TGA analyses. Terpolymeric gel formation in aqueous media was confirmed by the equilibrium swelling state and higher elastic modulus analyses. The pH stimuli responsiveness was investigated using different pH solutions mainly pH 2.5 and 7.4. As evident from the texture profile analysis, as the concentration of PEGDA increased in the AHP hydrogel, the hardness, adhesiveness and chewiness of the hydrogel enhanced significantly. Similarly, the higher concentration of PEGDA resulted in higher osteoblastic cell viability and increased rates of cell proliferation than hydrogels with lower concentrations of PEGDA. The release behaviour of the AHP hydrogels indicated that the more sustained release was observed in the hydrogels containing higher concentrations of PEGDA, especially in case of bovine serum albumin (BSA) and 5-amino salicylic acid (5-ASA). Overall, from the results it is evident that the pH-responsiveness and the biocompatibility of the AHP hydrogels showed affirmative potential as a carrier for protein (BSA), and 5-ASA delivery with improved mechanical properties and enhanced surface morphology. |
| 저자 |
Dipankar Das1, Gopinathan Janarthanan2, Hien Thi Thu Pham1, 이성호1, 노인섭1
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| 소속 |
1서울과학기술대, 2Seoul National Univ. of Science and Technology |
| 키워드 |
Hydrogel; Biomedical; Terpolymer
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| E-Mail |
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