| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
나노_포스터 |
| 제목 |
Drug-Loaded Modified Ceria-Zirconia Nanoparticles as an Enhanced Efficiency for Liver Disease Treatment |
| 초록 |
Chemotherapy is one of the significant approach for in vivo disease includes cancer treatment but has important challenges, such as cancer cell resistance and various side effect to normal tissue. Here, we have designed and synthesized an effective liver disease treatment agent based on monodisperse ceria-zirconia nanoparticles, which are loaded with drug (which was a typically drug for hepatocellular carcinoma (HCC)) and modified with binding to the hepatocarcinoma A54 peptide (sequence AGKGTPSLETTP) and poly(ethylene glycol) on their surface (S-A54/P-CeZr). The physicochemical properties were confirmed by FE-TEM (Field-emission Transmission Electron Microscope), EDS (Energy-Dispersive X-ray Spectroscopy), DLS (Dynamic Light Scattering), TGA (Thermogravimetric Analysis), 1H-NMR (1H Nuclear Magnetic Resonance) analyses. |
| 저자 |
홍상은1, 김옥희2, 홍하은2, 김세준2, 윤국로1
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| 소속 |
1한남대, 2가톨릭대 |
| 키워드 |
ceria-zirconia nanoparticles; surface modification; liver disease; drug delivery; sorafenib
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| E-Mail |
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