| 초록 |
Targeting therapeutic materials with superparamagnetic iron oxide nanoparticles (SPION) gained greater attention in the biomedical field. Generally, particles carrying different core sizes and various coatings were used in in vitro and in vivo. According to their desired purpose, they were also additionally functionalized with drugs, plasmids, peptides or proteins of interest. The p53 gene is a tumor suppressor and genome defense. It plays important role in various activities like cell cycle regulation, apoptosis, and DNA repair. In this study, we proposed gene carrying SPION for anti-cancer gene therapy. thermally crosslinked SPION was conjugated with branched PEI (bPEI) 1800Da by EDC-NHS chemistry for DNA delivery. |
