| 학회 |
한국화학공학회 |
| 학술대회 |
2009년 가을 (10/22 ~ 10/23, 일산 KINTEX) |
| 권호 |
15권 2호, p.1594 |
| 발표분야 |
생물화공 |
| 제목 |
High throughput identification of microbial pathogens causing bloodstream infections by using microarray |
| 초록 |
The spectrum of pathogens causing bacteremia with high mortality is gradually becoming wider, causing serious healthcare problems worldwide. The current blood culture system followed by biochemical tests requires long time to obtain results with low specificities. Thus, there has been much interest in developing microarrays for detecting pathogens in the blood. Here, we report the DNA microarray for detecting 57 important blood-borne pathogens. The microarray showed that all target DNAs from reference strains hybridized strongly to specific probes from their respective sequences. The microarray correctly identified pathogens in 103 out of 112 blood positive culture samples. Therefore, the microarray in this study should be useful for identifying blood-borne pathogens in clinical setting. [This work was supported by the Korean Systems Biology Project, WCU program (R32-2008-000-10142-0) from the Ministry of Education, Science and Technology, Medigenes Co. and LG Chem Chair Professorship] |
| 저자 |
유승민1, 최준용2, 윤정국3, 최재경3, 이경원2, 김준명2, 한민선1, 이상엽1
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| 소속 |
1한국과학기술원, 2연세대, 3MediGenes |
| 키워드 |
Microarray; pathogens
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| E-Mail |
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| 원문파일 |
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