| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effect of DBP Gel on DBP/PLGA Nerve Guidance Channel for Spinal Cord Regeneration |
| 초록 |
In this study, we proposed to use poly(L-lactide-co-glycolide) (PLGA) nerve channel impregnated demineralized bone particle (DBP) using tissue-engineering principles for the repair of spinal cord injury. Schwann cells (SCs) were seeded on DBP/PLGA nerve channel and DBP gel. The spinal cord was completely transected horizontally at two levels (T7 and T8), and DBP/PLGA nerve channel seeded schwann cells was implanted in the lesion. For histological evaluation, the implants were removed after 2, 4 and 8 weeks and stained hematoxylin and eosin staining. Motor functional outcome measurements using the BBB scoring and sensory test performed every week for 8 weeks post injury. It was observed that the effects DBP gel in DBP/PLGA nerve channel with SCs cells. Control groups were used blank. In conclusion DBP gel in DBP/PLGA nerve channel under these conditions is potentially useful for the applications of tissue construction. This research was supported by WCU (R31-20029) and SCRC (SC4110) . |
| 저자 |
유현, 송정은, 이윤미, 심초록, 임동균, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
Demineralized bone particle; PLGA; Schwann cells (SCs)
|
| E-Mail |
|
