| 초록 |
Cross-linked natural polymers with excellent biocompatibility have been used as a dermal filler for skin beauty. Recently, many attempts have been made to increase the duration of natural polymer filler using synthetic polymers. Although the synthetic polymers such as polyesters have long-term stability compared to the natural polymers, acidic byproducts from the polyesters cause inflammation. In this study, multifunctional polymeric microspheres were prepared with ceramic nanoparticles and bioactive agent via the membrane emulsification method. In in vitro, the ceramic nanoparticles incorporated polymeric microspheres significantly reduced inflammation due to neutralization effect. Also, the multifunctional polymeric microsphere reduced collagen degradation with inhibited cellular senescence. In conclusion, these results are expected to be applicable not only for dermal fillers but also for the development of various implantable medical devices. |
