| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Dextran/PLGA double-layered microspheres for sustained release of doxorubicin |
| 초록 |
Biodegradable polymer microspheres have been extensively developed as drug carriers that alleviate burst release and control drug release profiles. In this study, we report a simple method to develop double-layered microspheres for controlled and sustained drug release. Microspheres had a double layered structure with dextran layer in the core and PLGA on the surface due to phase separation and encapsulated doxorubicin as a model drug in their core. The molecular weight and concentration of PLGA dominated the structure, in vitro degradation and drug release profiles of microspheres. Drug release profiles from dextran/PLGA double-layered microspheres can becontrolled by manipulating the thickness of shell of the microspheres. We anticipate great potential of dextran/PLGA double-layered microspheres for controlled and sustained drug delivery, given their simple formulation and the control of drug release profiles. |
| 저자 |
박종학1, 김세호1, 이준희1, 홍현혜1, 육순홍2, 이동원1, 유일수1, 이종문1, 강길선1
|
| 소속 |
1전북대, 2한남대 |
| 키워드 |
double layer; doxorubicin; dextran; microspheres
|
| E-Mail |
|
