| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-고분자 |
| 제목 |
Reduction-responsive, Diselenide Core-Cross-Linked Polymeric Micelles for Doxorubicin Delivery for application in Cancer Therapy |
| 초록 |
The design and fabrication of smart delivery systems that can efficiently deliver a payload to a targeted site in a controlled manner are immensely desirable in chemotherapy. We report the reduction-responsive drug delivery property of core-cross-linked (CCL) micelles of poly (ethylene oxide) 5k-b-poly (furfuryl methacrylate) 2k (PEO5k-b-PFMA2k) block copolymers produced using Diels-Alder reaction. Doxorubicin (DOX) was loaded into hydrophobic PFMA cores of the polymeric micelles, which were subsequently cross-linked with diselenide-containing cross-linker. DOX-loaded CCL micelles were stable at pH 7.4, while a significant DOX release was observed at pH 5.0 due to the protonation of DOX. The non-CCL and CCL micelles were found non-toxic to HFF-1 normal cells. However, DOX encapsulated CCL micelles showed significant cytotoxicity in HeLa cells. The confocal images showed that the DOX-loaded CCL micelles can quickly be internalized and efficiently deliver DOX into the HeLa cells. |
| 저자 |
조이준, 이시윤, YADAV SONYABAPU ASHOK, 임권택
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| 소속 |
부경대 |
| 키워드 |
drug delivery; micells; core cross linked
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| E-Mail |
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