| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Accelerate Wound Healing in Hyperglycemia by Injectable Gallic Acid - Conjugated Chitosan Hydrogel |
| 초록 |
The impaired wound healing in diabetes is one of the major challenges in healthcare presently. The development of a hydrogel which can accelerate the wound healing process in hyperglycemia is believed to bring sufficient benefit. In this study, gallic acid (GA) was conjugated on chitosan (CS) backbone: (1) To supply the reactive sites for gelation through HRP/H2O2 catalysis and (2) enhance the wound healing in hyperglycemia. Chitosan-gallic acid (CGA) conjugates were synthesized via EDC/NHS coupling reaction. The gelation and mechanical strength of hydrogel can be controlled by varying the HRP and H2O2 concentration. CGA hydrogel showed superior scavenging effect toward DPPH, OH. radical and H2O2. CGA also enhanced the migration of hDFBs in hyperglycemia. In conclusion, CGA hydrogel is expected to effectively use in supporting the diabetic wound healing by debilitating the oxidation stress. Acknowledgement: NRF-2018R1A2B2004529, 2018M3A9B5021319 |
| 저자 |
Dieu Linh Tran1, 박기동2, Phuong Le Thi2
|
| 소속 |
1Ajou Univ., 2아주대 |
| 키워드 |
Hydrogel; chitosan; antioxidant; wound healing
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| E-Mail |
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