| 초록 |
Although the development of surgical techniques for tendon injury are rapidly growing, insufficient regeneration of tendon and inevitably occurred tissue adhesion during the healing process continues to be a challenge for orthopedic surgeons. To overcome the limitations, delivery of cells/growth factors (for tendon regeneration); drug therapy, physical barrier, physical rehabilitation training (for prevention of tissue adhesion) are intensively investigated. In this study, we developed a bi-layered Janus membrane which can enhance tendon regeneration (by sustained release of PDGF-BB from unique pore structure; tissue regeneration layer) and prevent tissue adhesion (by physical separation of alginate between defect and surrounding tissues; anti-tissue adhesion layer). The morphology, growth factor release behavior, tenogenic differentiation (on bioactive layer), and cell adhesiveness (on anti-tissue adhesion layer) are investigated |
