| 학회 |
한국공업화학회 |
| 학술대회 |
2005년 가을 (10/28 ~ 10/29, 건국대학교) |
| 권호 |
9권 2호 |
| 발표분야 |
정밀화학 |
| 제목 |
Efficient Synthesis of (2S,3S,4S)-3,4-Dihydroxyglutamic Acid |
| 초록 |
Glutamic acid is the major excitatory neurotransmitter of the central nervous system and its analogues are also shown to possess various biological activities. One of its dihydroxyl analogues, (3S,4S)-dihydroxy-L-glutamic acid that is shown to be a selective agonist for mGluR1, was synthesized efficiently with ca. 10:1 stereoselectivity via the N-ketimine group-controlled dihydroxylation reaction of (Z)-γ-amino-α, β-unsaturated ester that was derived from N-t-Boc-O-Benzyl-L-serine. |
| 저자 |
김정원, 전종호, 김영규
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| 소속 |
서울대 |
| 키워드 |
(Z)-unsaturated ester; Ketimine; Dihydroxylation reaction
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| E-Mail |
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