| 초록 |
Adhesions at the surfaces of diverse internal organs are difficult to achieve successfully due to the wet environment in the body. In addition, to be safely used, it must be biodegradable, and the decomposed products must be non-toxic. To secure these features, we fabricated an alternative tissue adhesive in the form of a dried patch obtained by crosslinking of bioengineered mussel adhesive protein (MAP) to polymer. When it soaked by water, strong adhesion is achieved by attractive forces such as the Dopa residues of MAP and the van der Waals force of the polymer. This patch also had the characteristics that the time it takes for decomposition in the body to be controlled from several days to several weeks. Through these characteristics, it is possible to provide a customized patch that performs successful adhesion under conditions most suitable for various environments in the body. Our developed water-adjustable and time-controllable adhesive patch might be useful as a tissue adhesive and sealant and for attaching sensors to wet tissues. |
